Slouching Towards Oblivion

Tuesday, May 26, 2020

It's The Endothelium, Stupid

Dr Seheult:


The WaPo piece:

Researchers who examined the lungs of patients killed by covid-19 found evidence that it attacks the lining of blood vessels there, a critical difference from the lungs of people who died of the flu, according to a report published Thursday in the New England Journal of Medicine.

Critical parts of the lungs of patients infected with the novel coronavirus also suffered many microscopic blood clots and appeared to respond to the attack by growing tiny new blood vessels, the researchers reported.

The observations in a small number of autopsied lungs buttress reports from physicians treating covid-19 patients. Doctors have described widespread damage to blood vessels and the presence of blood clots that would not be expected in a respiratory disease.

“What’s different about covid-19 is the lungs don’t get stiff or injured or destroyed before there’s hypoxia,” the medical term for oxygen deprivation, said Steven J. Mentzer, a professor of surgery at Harvard Medical School and part of the team that wrote the report. “For whatever reason, there is a vascular phase” in addition to damage more commonly associated with viral diseases such as the flu, he said.

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