Slouching Towards Oblivion

Monday, August 10, 2020

COVID-19 Update

The Monday lull.

Still waiting to see if the numbers start to drop consistently, and if that's "normal" - which is unlikely because these things don't "just disappear" in spite of what President Stoopid says to the contrary - or if the plan to fuck with those numbers is working and that's what we're actually seeing.

A contagion will in fact "run its course". It'll go as far as it can go, and assuming it leaves behind an acquired immunity in those who survive it, then it'll look like it "just disappeared" because enough of us will stop being susceptible to it (the miracle of herd immunity).

But that assumes the magic of acquired immunity, and while there's probably reason to expect it, there's no solid body of evidence on it yet.

In fact, the evidence is making the pros a little antsy and unsure right now.

Scientific American:

COVID-19 triggers a strong immune response in most people. Yet several recent studies observed that the amounts of antibodies in those recovering from the virus appear to decline within a few months of infection. The findings set off a frenzy of speculation that immunity to the virus may not last long, throwing cold water on hopes for a vaccine. Many scientists say such worries are overblown, however.

A June 18 Nature Medicine study conducted with a small group of patients in China showed that in both asymptomatic and symptomatic individuals with COVID-19, antibody levels dropped significantly during recovery—and that the levels became undetectable in 40 percent of the asymptomatic group. A preprint study by researchers in England that was posted online in mid-July similarly demonstrated that antibody levels declined substantially within a few months of infection and that people with less severe illness had fewer antibodies. And most recently, a small study, published on July 21 in the New England Journal of Medicine, found a “rapid decay” in antibodies among individuals with mild cases of COVID-19.

These results may sound universally grim. But several experts Scientific American spoke with said they thought that the declines were not as scary as initially portrayed, that some reduction in antibodies is normal and expected and that antibodies are just one piece of the immunity puzzle. Evidence from other viruses and animal studies of SARS-CoV-2 infection provide reason for optimism, they add. That assessment is no doubt reassuring for vaccine developers, some of whom are already racing ahead with large-scale clinical trials. Only longer follow-up studies of people infected with the novel coronavirus will show whether antibodies confer lasting protection, however.

We're in for a long ride.




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