Back To The Gilded Age

A little reminder of the damage a bad president can do.

Vox:

Since the election of Donald Trump, there’s been a lot of discussion in medical circles about bringing a Silicon Valley ethos to drug innovation in America.

This idea is embodied in Peter Thiel, the billionaire founder of PayPal, who has reportedly been helping the president vet a pool of candidates to lead the Food and Drug Administration.

Thiel, a libertarian iconoclast, has repeatedly made the case that the FDA gets in the way of drug innovation by making it too difficult for new medicines to get to the market. Some of the FDA candidates he’s identified — including Silicon Valley’s Jim O’Neill and Balaji Srinivasan — have similarly argued that the agency should dump its requirement that drugs be proven effective before reaching the market, and that we’d be better off if the FDA operated more like a “Yelp for drugs.” In other words, bringing the same speedy and disruptive approach to medical regulation that Silicon Valley brought to the taxi and hotel industries, for example, will unlock cures — fast.

But Thiel and his pals miss a very important point about developing new drugs: Manipulating biology isn’t the same as manipulating computer code. It’s much, much harder. Speeding up medical innovation will take a lot more than just stripping down the FDA — it’ll take huge leaps forward in our understanding of biochemistry and the body. Health care is also different from taxis and hotels in another key way: Consumers can’t really judge the safety and quality of medical products by themselves.

Trump to remove USDA animal welfare protections from cruelty for dogs. A reminder from 9/16: he's never HAD a dog pic.twitter.com/NykVqnG6Nj

— Keith Olbermann (@KeithOlbermann) February 4, 2017

So, like, one of the things Da Gubmint is there trying to do for you is to keep some asshole from killing your dog.  If you can't quite work yourself up to giving a fuck about people, maybe you could think about finding a little compassion for their fucking house pets.

More from the Vox piece:

One of the key notions that undergirds the Peter Thiel view of the FDA is that if the agency just got rid of some of the pesky restrictions for drug approval, we’d usher in another golden age in drug development. (Thiel declined our interview request.)

To test this idea, I asked a longtime pharmaceutical scientist (and conservative), Derek Lowe, for his views. In his 28 years in the lab, Lowe has seen hundreds of thousands of compounds tested on a huge variety of drug targets, and never, not once, has he brought a drug to market.

The reason? “We don’t know how to find drugs that work,” he said.

For every 5,000 compounds discovered at this "preclinical" phase of drug development, only about five are promising enough to be tried in humans. That’s a success rate of 0.1 percent.

Drug innovation comes from painstaking tinkering and a dash of luck. “It’s very tempting for someone who has come out of IT to say, ‘DNA is code, and cells are the hardware; go in and debug it’,” Lowe said. “But this is wrong.”

Let's just try to remember one or two itty-bitty things, OK?

You were supposed to have read that shit way back in high school, y'know.

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