For me, there's nothing better than listening to smart people explain things to me.
Bookmark it, and come back later if you have to, but this shit is important.
Since the election of Donald Trump, there’s been a lot of discussion in medical circles about bringing a Silicon Valley ethos to drug innovation in America.
This idea is embodied in Peter Thiel, the billionaire founder of PayPal, who has reportedly been helping the president vet a pool of candidates to lead the Food and Drug Administration.
Thiel, a libertarian iconoclast, has repeatedly made the case that the FDA gets in the way of drug innovation by making it too difficult for new medicines to get to the market. Some of the FDA candidates he’s identified — including Silicon Valley’s Jim O’Neill and Balaji Srinivasan — have similarly argued that the agency should dump its requirement that drugs be proven effective before reaching the market, and that we’d be better off if the FDA operated more like a “Yelp for drugs.” In other words, bringing the same speedy and disruptive approach to medical regulation that Silicon Valley brought to the taxi and hotel industries, for example, will unlock cures — fast.
But Thiel and his pals miss a very important point about developing new drugs: Manipulating biology isn’t the same as manipulating computer code. It’s much, much harder. Speeding up medical innovation will take a lot more than just stripping down the FDA — it’ll take huge leaps forward in our understanding of biochemistry and the body. Health care is also different from taxis and hotels in another key way: Consumers can’t really judge the safety and quality of medical products by themselves.
Trump to remove USDA animal welfare protections from cruelty for dogs. A reminder from 9/16: he's never HAD a dog pic.twitter.com/NykVqnG6Nj— Keith Olbermann (@KeithOlbermann) February 4, 2017
One of the key notions that undergirds the Peter Thiel view of the FDA is that if the agency just got rid of some of the pesky restrictions for drug approval, we’d usher in another golden age in drug development. (Thiel declined our interview request.)
To test this idea, I asked a longtime pharmaceutical scientist (and conservative), Derek Lowe, for his views. In his 28 years in the lab, Lowe has seen hundreds of thousands of compounds tested on a huge variety of drug targets, and never, not once, has he brought a drug to market.
The reason? “We don’t know how to find drugs that work,” he said.
For every 5,000 compounds discovered at this "preclinical" phase of drug development, only about five are promising enough to be tried in humans. That’s a success rate of 0.1 percent.
Drug innovation comes from painstaking tinkering and a dash of luck. “It’s very tempting for someone who has come out of IT to say, ‘DNA is code, and cells are the hardware; go in and debug it’,” Lowe said. “But this is wrong.”
But Trump - who puts a premium on loyalty and has demonstrated great interest in having forceful security at his events - has opted to maintain an aggressive and unprecedented private security force, led by Keith Schiller, a retired New York City cop and Navy veteran who started working for Trump in 1999 as a part-time bodyguard, eventually rising to become his head of security.
Security officials warn that employing private security personnel heightens risks for the president-elect and his team, as well as for protesters, dozens of whom have alleged racial profiling, undue force or aggression at the hands Trump’s security, with at least 10 joining a trio of lawsuits now pending against Trump, his campaign or its security.--and--
The Trump associates say Schiller is expected to become a personal White House aide who would serve as the incoming president’s full-time physical gatekeeper, though he might not be able to offer his boss the wide range of services he has in the past. For instance, federal law prohibits anyone other than law enforcement officers from bringing firearms into federal buildings, and there are even stricter rules about who can carry on the White House grounds or around Secret Service protectees. Schiller had been armed at times early in the campaign, but it’s unclear if he continued carrying a firearm after Trump was granted Secret Service protection in November 2015.
Even after the arrival of Trump’s Service detail, which typically marks the end of any pre-existing security arrangement, Schiller never strayed from his boss’s side.
The associates say Schiller provides more than just security. Trump has been known to ask Schiller’s opinion on all manner of subjects. When people want to reach Trump, they often call Schiller’s cell phone and he decides who gets through to the boss.Trump just can't help but pick these fights - in his typical Passive Aggressive style - even to the point where he's saying he doesn't trust the professionalism of an agency sworn to serve - people who're trained to take a bullet if that's what's necessary to protect The President, no matter who that president is or what they do or don't have in common with that president.
Climate change poses another significant challenge for the United States and the world at large. As greenhouse gas emissions increase, sea levels are rising, average global temperatures are increasing, and severe weather patterns are accelerating. These changes, coupled with other global dynamics, including growing, urbanizing, more affluent populations, and substantial economic growth in India, China, Brazil, and other nations, will devastate homes, land, and infrastructure. Climate change may exacerbate water scarcity and lead to sharp increases in food costs. The pressures caused by climate change will influence resource competition while placing additional burdens on economies, societies, and governance institutions around the world. These effects are threat multipliers that will aggravate stressors abroad such as poverty, environmental degradation, political instability, and social tensions – conditions that can enable terrorist activity and other forms of violence.
CHAPTER I: FUTURE SECURITY ENVIRONMENT 8(quick little note - this kind of straight-up declarative statement doesn't make the final cut without the approval of a lotta people who wear some very heavy hats)
e·nor·mous
adj.
1. Very great in size, extent, number, or degree.
2. Archaic Very wicked; heinous.
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