About the hardest thing ever is to forgive somebody when they've betrayed you.
It's not impossible, but there has to be contrition, and atonement, and a demonstration of changed behaviors and attitudes.
I'll say it again:
Dec 14, 2025
Dec 13, 2025
Today's Belle
Throwing your weight around doesn't make you look strong - it makes you look unstable. And that makes the people around you look for better, more reliable friends.
Jimmy Kimmel
They treat him like he's three years old - because that's how he behaves.
- He demands attention
- He needs instant gratification
- He has to be constantly praised for nothing
- He needs plenty of nap time
- They order in McDonalds for him two or three times a day
- He has ice cream after every meal
- He uses a Sharpie when he's not supposed to
- He wants to hear the same two songs over and over
- He wears diapers
He's three years old!
A Prized Woman
I can't even spell half the shit this woman knows like the back of her hand.
Congratulations to Dr. Mary Brunkow on receiving the 2025 Nobel Prize in Physiology or Medicine this week in Stockholm.
And to think a drugged up roids ranger with a dead worm in his brain has been put in charge of our national health policy.
Stay home, try to eat right, and get some exercise. This ridiculous charade will pass, and we have to be ready for the massive rebuilding effort we'll have to make on the other side of it.
In her acceptance speech on Wednesday, Dr. Brunkow reflected: "As a woman in science I especially want to acknowledge those role models who gave me the courage and incentive to persevere. My hope is that I in turn can be that role model for my own daughters, who are just now launching out into the world, as well as for other young women who are excited about science."
Dr. Brunkow was honored for groundbreaking discoveries concerning peripheral immune tolerance, which prevents our immune system from attacking the body's own tissues. She identified the gene that controls regulatory T cells -- a previously unknown class of immune cells that act as security guards to keep harmful immune responses in check.
The American scientist shared the prize with Fred Ramsdell, also from the United States, and Shimon Sakaguchi from Japan, who made complementary contributions to understanding peripheral immune tolerance. The discoveries have laid the foundation for a new field of research and spurred the development of treatments for autoimmune diseases and cancer. As Olle Kämpe, chair of the Nobel Committee, explained, their research has "been decisive for our understanding of how the immune system functions and why we do not all develop serious autoimmune diseases."
Brunkow received her Ph.D. from Princeton University in 1991 in molecular biology and is currently a senior researcher at the Institute for Systems Biology in Seattle. Her Ph.D. adviser, former Princeton President Shirley M. Tilghman, described her as "incredibly bright" and "bold," noting that as a student, Brunkow was one of the first brave enough to tackle the mysterious H19 gene, which other scientists had dismissed as junk.
Brunkow and Ramsdell conducted their prize-winning research together at Celltech Chiroscience in 2001, when they identified a mutation in the FOXP3 gene in a mouse strain suffering from lethal autoimmunity. They explained why this specific type of mouse was particularly vulnerable to autoimmune diseases and showed that mutations in the human equivalent of this gene cause IPEX syndrome, a serious autoimmune disease. In 2003, Sakaguchi linked their findings to his earlier discovery of regulatory T cells from the 1990s, proving that the FOXP3 gene governs the development of these crucial immune regulators.
Brunkow, who is now the fourteenth woman to have won the Nobel Prize in Physiology or Medicine, described the regulatory T cells as "rare, but powerful, and they're critical for sort of dampening an immune response". She explained that these cells function as a braking system that prevents the body's immune system from tipping over into attacking itself. Their discoveries have led to potential treatments now in clinical trials for autoimmune diseases, cancer, and stem cell transplant complications.
Dr. Brunkow was honored for groundbreaking discoveries concerning peripheral immune tolerance, which prevents our immune system from attacking the body's own tissues. She identified the gene that controls regulatory T cells -- a previously unknown class of immune cells that act as security guards to keep harmful immune responses in check.
The American scientist shared the prize with Fred Ramsdell, also from the United States, and Shimon Sakaguchi from Japan, who made complementary contributions to understanding peripheral immune tolerance. The discoveries have laid the foundation for a new field of research and spurred the development of treatments for autoimmune diseases and cancer. As Olle Kämpe, chair of the Nobel Committee, explained, their research has "been decisive for our understanding of how the immune system functions and why we do not all develop serious autoimmune diseases."
Brunkow received her Ph.D. from Princeton University in 1991 in molecular biology and is currently a senior researcher at the Institute for Systems Biology in Seattle. Her Ph.D. adviser, former Princeton President Shirley M. Tilghman, described her as "incredibly bright" and "bold," noting that as a student, Brunkow was one of the first brave enough to tackle the mysterious H19 gene, which other scientists had dismissed as junk.
Brunkow and Ramsdell conducted their prize-winning research together at Celltech Chiroscience in 2001, when they identified a mutation in the FOXP3 gene in a mouse strain suffering from lethal autoimmunity. They explained why this specific type of mouse was particularly vulnerable to autoimmune diseases and showed that mutations in the human equivalent of this gene cause IPEX syndrome, a serious autoimmune disease. In 2003, Sakaguchi linked their findings to his earlier discovery of regulatory T cells from the 1990s, proving that the FOXP3 gene governs the development of these crucial immune regulators.
Brunkow, who is now the fourteenth woman to have won the Nobel Prize in Physiology or Medicine, described the regulatory T cells as "rare, but powerful, and they're critical for sort of dampening an immune response". She explained that these cells function as a braking system that prevents the body's immune system from tipping over into attacking itself. Their discoveries have led to potential treatments now in clinical trials for autoimmune diseases, cancer, and stem cell transplant complications.
(hat tip: A Mighty Girl)
Women will save us.
All we have to do is
stay the fuck out of their way
and let them do it.
Dec 12, 2025
Subscribe to:
Comments (Atom)